Investigating how fatty acids influence tumor spread and resistance in colorectal cancer
Fatty acids and their receptors-mediated tumor metastasis and progression
['FUNDING_R01'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-10771960
This study is looking at how certain fats in the body might help colorectal cancer grow and resist treatment, with the goal of finding new ways to improve care for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-10771960 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of fatty acids and their receptors in the metastasis and chemotherapy resistance of colorectal cancer (CRC). It aims to identify how specific lipid transporters, such as CD36 and MDR1, contribute to the progression of CRC by facilitating lipid uptake in tumor cells. The study will explore the types of lipids involved and how they affect cancer cell survival and resistance to treatment. By examining these mechanisms, the research seeks to uncover potential therapeutic targets for improving outcomes in CRC patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, particularly those with RAS or BRAF mutations and experiencing metastasis or resistance to chemotherapy.
Not a fit: Patients with early-stage colorectal cancer who have not yet undergone chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat metastasis and chemotherapy resistance in colorectal cancer patients.
How similar studies have performed: Previous research has shown that targeting lipid metabolism can impact cancer progression, suggesting that this approach may yield promising results.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, HUA E — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: YU, HUA E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer