Investigating how fatty acid oxidation affects heart protection in post-menopausal women
Fatty acid oxidation in female cardioprotection
This study is looking into why women have a higher risk of heart disease after menopause, focusing on how changes in estrogen affect heart health and fat processing, using mice to help find answers that could benefit women in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10983760 on NIH RePORTER |
What this research studies
This research explores the reasons why women experience increased cardiovascular disease risk after menopause. It focuses on the role of estrogen and its impact on fatty acid oxidation in the heart. By studying mouse models, the researchers aim to uncover how changes in estrogen levels affect heart metabolism and protection. The study will involve examining specific enzymes that regulate fatty acid oxidation and their relationship to heart health in post-menopausal females.
Who could benefit from this research
Good fit: Ideal candidates for this research are post-menopausal women who are at risk for cardiovascular diseases.
Not a fit: Patients who are pre-menopausal or have existing severe cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing heart disease in post-menopausal women.
How similar studies have performed: Other research has indicated that understanding estrogen's role in heart health could lead to significant advancements, but this specific approach is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Scott, Iain — University of Pittsburgh at Pittsburgh
- Study coordinator: Scott, Iain
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.