Investigating how fats in blood vessels affect Alzheimer's disease
Official title: The role of vascular lipids in Alzheimer's disease pathophysiology
Funded at University of California, San Diego · NIH-10915444 · Data updated 2026-11-12
This study is looking at how the fats in the blood vessels of the brain might affect the development of Alzheimer's disease, and it's for anyone interested in understanding how changes in these blood vessels could impact brain health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $41,825 |
| NIH project number | 5F31AG084272-02 |
| Project ID | NIH-10915444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the role of blood vessels in the brain and how their lipid composition may influence the development of Alzheimer's disease. By examining the unique properties of the blood-brain barrier and its impact on brain health, the study aims to uncover how disruptions in vascular function contribute to Alzheimer's pathology. The researchers will utilize a specialized proteomic approach to identify changes in lipid-related enzymes in the blood vessels of Alzheimer's patients compared to healthy individuals.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets.
How similar studies have gone: Previous research has indicated that vascular dysfunction plays a significant role in Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Harvey, Sean Sandas — University of California, San Diego
- Study coordinator: Harvey, Sean Sandas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.