Investigating how FAT1 gene mutations affect the aggressiveness of head and neck cancer
Role of FAT1 somatic mutations in aggressiveness of head and neck cancer
['FUNDING_R03'] · EMORY UNIVERSITY · NIH-10669277
This study is looking at how changes in the FAT1 gene might affect the behavior of head and neck cancer, with the goal of finding new ways to personalize treatment for patients.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10669277 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of FAT1 gene mutations in head and neck squamous cell carcinoma (HNSCC). By analyzing existing genomic and proteomic data, the study aims to identify how these mutations influence cancer aggressiveness through changes in protein expression and immune regulatory networks. The researchers will validate their findings using biological assays and correlate them with patient clinical outcomes to identify potential biomarkers for treatment response. This approach could lead to better-targeted therapies for patients with HNSCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with head and neck squamous cell carcinoma, particularly those with FAT1 mutations.
Not a fit: Patients with head and neck cancer who do not have FAT1 mutations may not benefit directly from the findings of this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with head and neck cancer by identifying new biomarkers for aggressiveness and treatment response.
How similar studies have performed: Previous studies have shown promising results in understanding the role of genetic mutations in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TENG, YONG — EMORY UNIVERSITY
- Study coordinator: TENG, YONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers