Investigating how fat tissue affects ovarian cancer growth and treatment resistance
Adipose tissue immunometabolism in ovarian cancer progression and chemoresistance
This study is looking at how fat cells in the body might affect ovarian cancer and its response to chemotherapy, with the goal of finding better treatment options and personalized approaches for patients facing challenges with their current therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11084290 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of adipose tissue in the progression of ovarian cancer and its resistance to chemotherapy. By examining how fat cells interact with cancer cells, the study aims to identify new therapeutic strategies that could improve treatment outcomes for patients. The approach includes exploring different classes of microtubule-targeted agents and their effects on cancer signaling pathways. Additionally, the research seeks to discover biomarkers that can help tailor treatment options for patients with ovarian cancer who have developed resistance to standard therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with ovarian cancer, especially those experiencing resistance to chemotherapy treatments.
Not a fit: Patients with early-stage ovarian cancer who have not yet undergone chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with ovarian cancer, particularly those who have become resistant to current therapies.
How similar studies have performed: Previous research has shown promise in targeting cancer resistance mechanisms, indicating that this approach could yield significant advancements in treatment.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Yee, Samantha — University of Chicago
- Study coordinator: Yee, Samantha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.