Investigating how fat tissue affects colorectal cancer development
Adipose Tissue Extracellular Vesicles in Colorectal Tumorigenesis
This study is looking at how tiny particles from fat tissue might affect the way certain cells in the colon behave, especially in people who are obese and at risk for colorectal cancer, to help us learn more about how this type of cancer develops.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Eastern Colorado Health Care System NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10881757 on NIH RePORTER |
What this research studies
This research explores the role of extracellular vesicles (EVs) produced by adipose tissue in the development of colorectal cancer, particularly in obese individuals. It focuses on how these vesicles influence the metabolism and function of specific stem cells in the colon that are linked to cancer progression. By examining the molecular interactions between adipose tissue and colonic cells, the study aims to uncover new insights into the mechanisms that drive colorectal tumorigenesis. Patients may be involved in providing samples or data to help understand these processes better.
Who could benefit from this research
Good fit: Ideal candidates for this research are obese individuals, particularly veterans, who are at a higher risk for developing colorectal cancer.
Not a fit: Patients who are not obese or do not have a risk of colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colorectal cancer in obese patients.
How similar studies have performed: While the specific approach of studying adipose tissue-derived EVs in colorectal cancer is novel, related research has shown promising results in understanding the role of obesity in cancer development.
Where this research is happening
Aurora, UNITED STATES
- VA Eastern Colorado Health Care System — Aurora, United States (Active)
Researchers
- Principal investigator: Theiss, Arianne L — VA Eastern Colorado Health Care System
- Study coordinator: Theiss, Arianne L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.