Investigating how fat tissue affects brain health in older adults
Targeting adipose tissue thermogenesis for age-related vascular cognitive impairment
['FUNDING_CAREER'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-10898834
This study is looking at how fat tissue that helps keep us warm might affect brain health and thinking skills in older adults, especially those with memory problems, to find ways to help prevent or treat these issues.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10898834 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how changes in fat tissue, particularly its ability to generate heat, can influence brain health and cognitive function in older adults. The study aims to explore the relationship between microvascular health and cognitive decline, specifically in individuals suffering from vascular cognitive impairment and dementia. By examining the role of adipose tissue and its thermogenic properties, the research seeks to identify potential interventions that could prevent or treat cognitive decline associated with aging. Patients may be involved in assessments that monitor their vascular health and cognitive function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are experiencing vascular cognitive impairment or are at risk for dementia.
Not a fit: Patients who are younger than 65 or do not have any cognitive impairment or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in older adults.
How similar studies have performed: Other research has shown promising results in targeting metabolic processes to improve cognitive health, suggesting that this approach may hold potential for success.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BALASUBRAMANIAN, PRIYA — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: BALASUBRAMANIAN, PRIYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease and related dementia