Investigating how fat tissue affects asthma in obese children
Obesity and Childhood Asthma: The Role of Adipose Tissue
This study is looking at how being overweight might affect asthma in kids by checking their fat tissue, and it's for children with asthma, obesity, both, or those who are healthy, to help find new ways to improve their breathing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10991385 on NIH RePORTER |
What this research studies
This research explores the connection between obesity and childhood asthma by examining changes in fat tissue. It aims to understand how epigenetic and transcriptomic changes in adipose tissue contribute to asthma severity and control in children who are obese. The study will recruit children with asthma, obesity, both conditions, or healthy controls, and will analyze their fat tissue to identify genetic and molecular factors that may influence their respiratory health. By integrating various biological data, the research seeks to uncover new therapeutic targets for managing asthma in obese children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who are obese and have asthma, as well as those who have either condition or are healthy controls.
Not a fit: Patients who do not have asthma or obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve asthma management in obese children.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between obesity and asthma, but this approach is novel in its focus on adipose tissue epigenetics.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Forno, Erick — Indiana University Indianapolis
- Study coordinator: Forno, Erick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.