Investigating how fat quality affects heart health in obese monkeys
Adipose Mitochondial Quality Control and Cardiovascular Function in Metabolically Healthy and Unhealthy Obese Monkeys
This study looks at how the quality of fat in obese monkeys affects their heart health and risk of diseases like diabetes, and it also checks if losing weight can help improve their fat and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10541816 on NIH RePORTER |
What this research studies
This research explores the differences in fat tissue quality between metabolically healthy obese monkeys and those with unhealthy obesity. By studying these monkeys, researchers aim to understand how mitochondrial function in fat tissue influences cardiovascular health and the potential for developing diseases like diabetes. The study will also examine how weight loss might improve fat tissue characteristics and overall health. This research uses advanced biological techniques to analyze fat tissue and its impact on heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who are classified as metabolically healthy obese or unhealthy obese.
Not a fit: Patients who are not obese or do not have related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cardiovascular diseases in obese individuals.
How similar studies have performed: Other research has shown promising results in understanding fat tissue's role in metabolic health, but this specific approach using a monkey model is relatively novel.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Kavanagh, Kylie — Wake Forest University Health Sciences
- Study coordinator: Kavanagh, Kylie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.