Investigating how fat metabolism affects liver injury during surgery
Official title: Role of Lipid Metabolism in Hepatic Ischemia Reperfusion Injury in Steatotic Livers
Funded at Washington University · NIH-11046561 · Data updated 2026-11-12
This study is looking at how fat in the liver affects liver damage during surgery, and it hopes to find ways to help the liver heal better by understanding how fat and the immune system work together, which could lead to better treatments for people with liver issues related to fat.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | May 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $160,871 |
| NIH project number | 5K08DK131255-03 |
| Project ID | NIH-11046561 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with steatotic livers or conditions related to fatty liver disease.
✕Less likely to help
Patients without liver conditions or those who do not have steatosis may not receive any benefit from this research.
What this research studies
This research focuses on understanding how lipid metabolism influences liver injury that occurs during surgical procedures, particularly in livers that have excess fat (steatosis). The study aims to explore the mechanisms behind this injury and how manipulating lipid pathways can impact inflammation and liver cell recovery. By examining various lipid metabolic pathways and immune cell responses, the research seeks to identify potential therapeutic targets to improve liver health. Patients may benefit from insights gained into how to better manage liver conditions related to fat accumulation.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver injury in patients with fatty liver disease.
How similar studies have gone: Previous research has shown promising results in understanding liver injury mechanisms related to lipid metabolism, indicating that this approach has potential for success.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Liss, Kim Hung Ho — Washington University
- Study coordinator: Liss, Kim Hung Ho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.