Investigating how fat metabolism affects liver and fat tissue health
Thioesterase-mediated lipotoxicity in liver and thermogenic adipose tissue
This study is looking at how extra fat from obesity can cause liver problems and is exploring how certain enzymes help break down fat, with the hope of finding new treatments for people dealing with obesity-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11090452 on NIH RePORTER |
What this research studies
This research focuses on understanding how obesity-related fat toxicity leads to non-alcoholic fatty liver disease (NAFLD). It explores the role of specific enzymes, called acyl-CoA thioesterases, in breaking down fatty acids and how their activity can influence metabolic diseases. By studying these mechanisms, the research aims to identify new treatment options for patients suffering from obesity-related conditions. Patients may benefit from insights that could lead to novel pharmacological interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from obesity or metabolic disorders, particularly those at risk for non-alcoholic fatty liver disease.
Not a fit: Patients who are not affected by obesity or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity-related liver diseases and improve metabolic health.
How similar studies have performed: Previous research has shown promising results in understanding fat metabolism and its implications for liver health, suggesting that this approach could yield significant insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Ersoy, Baran — Weill Medical Coll of Cornell Univ
- Study coordinator: Ersoy, Baran
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.