Investigating how fat distribution and function change in people with HIV on antiretroviral therapy
Pathophysiology of Metabolically Detrimental Changes in Adipose Distribution, Adipocyte Function, and Adipose Immune Environment on Antiretroviral Therapy
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11021044
This study is looking at how gaining extra fat and where that fat is stored affects the health of people with HIV who are on treatment, with the goal of finding ways to help them stay healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11021044 on ClinicalTrials.gov |
What this research studies
This research explores how excess fat accumulation and changes in fat distribution affect the health of individuals living with HIV who are undergoing antiretroviral therapy. It focuses on understanding the mechanisms behind weight gain and fat deposition, particularly in visceral areas, and how these changes contribute to increased risks of cardiometabolic diseases. The study employs advanced techniques such as imaging and genetic analysis of fat cells to uncover the underlying biological processes. By examining the relationship between energy balance and fat storage, the research aims to identify potential interventions to improve health outcomes for these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are starting or currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those not undergoing antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing weight and reducing the risk of heart and metabolic diseases in people with HIV on antiretroviral therapy.
How similar studies have performed: Previous research has shown promising results in understanding fat distribution and metabolic changes in HIV patients, indicating that this approach has potential for significant insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOETHE, JOHN — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: KOETHE, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, adult onset diabetes, Adult-Onset Diabetes Mellitus