Investigating how fat diets affect breast cancer risk through lipid metabolism
Determine the role of SETDB1 in controlling lipid metabolism in obesity-associated cancer
This study is looking at how eating a lot of fatty foods might affect the risk of breast cancer, especially for people who are overweight, by focusing on a protein that could be important in this connection, and it hopes to help patients learn how their diet might influence their cancer risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11073270 on NIH RePORTER |
What this research studies
This research aims to explore the connection between high-fat diets and breast cancer risk by examining how lipid metabolism is altered in obesity. The study focuses on a specific protein, A-FABP, which may play a crucial role in promoting breast cancer in individuals with obesity. By analyzing how different types of high-fat diets influence this protein and the immune response in the body, the research seeks to uncover new insights into the mechanisms linking obesity and breast cancer. Patients may benefit from understanding how dietary choices could impact their cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are obese and at risk for breast cancer, particularly those with a history of high-fat diet consumption.
Not a fit: Patients who are not obese or do not have a risk of breast cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing breast cancer in obese individuals by targeting lipid metabolism.
How similar studies have performed: Previous studies have shown promising results in understanding the links between obesity and cancer, but this specific approach focusing on A-FABP is relatively novel.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Li, Bing — University of Iowa
- Study coordinator: Li, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.