Investigating how fat-derived signals affect kidney cancer metabolism
Adipokine Signaling as a Therapeutically Targetable Driver of Tumor Metabolism
This study is looking at how a fat-related protein called Chemerin might affect the growth of kidney cancer, specifically the most common type, and it aims to find new ways to treat this cancer by blocking Chemerin's effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11041108 on NIH RePORTER |
What this research studies
This research explores the connection between obesity and clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer. It focuses on a specific fat-derived protein called Chemerin, which may play a crucial role in how tumors grow by altering their metabolism. The study employs various methods, including animal models, to test the effects of inhibiting Chemerin and to understand its mechanisms of action on both tumor and non-tumor cells. By targeting this adipokine, the research aims to identify new therapeutic strategies for treating ccRCC.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with clear cell renal cell carcinoma, particularly those with obesity or metabolic syndrome.
Not a fit: Patients with other types of kidney cancer or those without obesity-related metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with clear cell renal cell carcinoma, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach may yield significant advancements.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Welford, Scott Michael — University of Miami School of Medicine
- Study coordinator: Welford, Scott Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.