Investigating how fat cells produce uridine and its effects on obesity and diabetes
The Role of Adipocyte Uridine Biosynthesis in Obesity and Diabetes Progression
This study is looking at how fat cells in our bodies produce a substance called uridine and how this might influence obesity and diabetes, especially when we eat a lot of fatty foods, to find new ways to help manage these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10896245 on NIH RePORTER |
What this research studies
This research explores the role of adipocytes, or fat cells, in producing uridine, a nucleoside that plays various roles in the body. The study aims to understand how increased uridine levels from fat cells affect obesity and diabetes progression, particularly under conditions of stress caused by a high-fat diet. By examining the relationship between uridine production and insulin resistance, the research seeks to uncover potential mechanisms that could lead to new treatment strategies for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are experiencing obesity or have been diagnosed with diabetes, particularly those with insulin resistance.
Not a fit: Patients who are not overweight or do not have diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for managing obesity and diabetes by targeting uridine production in fat cells.
How similar studies have performed: While the role of uridine in metabolism is known, this specific investigation into adipocyte uridine production and its implications for obesity and diabetes is relatively novel.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Deng, Yingfeng — Beckman Research Institute/city of Hope
- Study coordinator: Deng, Yingfeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.