Investigating how fat cell aging affects metabolism in older adults
Official title: Lipid Metabolism, Mitochondrial Stress, and Senescence
Funded at University of Minnesota · NIH-10826906 · Data updated 2026-11-12
This study is looking at how the buildup of old fat cells can cause health problems like insulin resistance and inflammation in older adults, especially those who are obese, and it hopes to find new ways to understand and improve these issues with your help through samples or data.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 1F32AG086035-01 |
| Project ID | NIH-10826906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older, particularly those experiencing metabolic dysfunction or obesity.
✕Less likely to help
Patients under the age of 65 or those without metabolic issues may not benefit from this research.
What this research studies
This research focuses on understanding how the accumulation of aging fat cells in the body contributes to metabolic issues commonly seen in older adults, particularly those who are obese. The study examines the role of harmful byproducts produced during fat metabolism, which may lead to inflammation and insulin resistance. By analyzing how these byproducts affect fat cell function and promote aging, the research aims to uncover new insights into age-related metabolic dysfunction. Patients may be involved in providing samples or data to help characterize these processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for metabolic disorders in older adults, improving their overall health and quality of life.
How similar studies have gone: Previous research has shown that targeting cellular aging and metabolic dysfunction can lead to significant health improvements, suggesting that this approach may also yield promising results.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Monroe, Blake — University of Minnesota
- Study coordinator: Monroe, Blake
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.