Investigating how famotidine may help the right heart in pulmonary hypertension
The Pulmonary Hypertension- Multi-Dimensional Omics to Characterize Right Heart Adaptation (PH-MOCHA) study
This study is looking at how the medication famotidine might help people with pulmonary arterial hypertension and right heart failure feel better and improve their heart function over 24 weeks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10625989 on NIH RePORTER |
What this research studies
This research focuses on understanding the effects of famotidine, an H2 receptor antagonist, on patients with pulmonary arterial hypertension (PAH) and right heart failure. Participants will be enrolled in a clinical trial where they will receive famotidine for 24 weeks to assess its impact on right heart function and overall health. The study will measure various outcomes, including exercise capacity, heart function, and quality of life, using advanced biological analysis techniques to identify which patients may benefit most from this treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with pulmonary arterial hypertension who are experiencing right heart failure.
Not a fit: Patients without pulmonary arterial hypertension or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for improving right heart function in patients with pulmonary hypertension.
How similar studies have performed: While the approach of using famotidine in this context is novel, previous studies have shown promise in targeting right heart function in pulmonary hypertension.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Leary, Peter J — University of Washington
- Study coordinator: Leary, Peter J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.