Investigating how factors from bones affect blood vessel aging
Identifying A Skeleton-Derived Factor for Vascular Aging
This study is looking at how bone health affects blood vessel aging in people 65 and older, to find out if certain substances from bones can help us understand and improve heart health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11005062 on NIH RePORTER |
What this research studies
This research explores the relationship between bone health and vascular aging, particularly in individuals aged 65 and older. It aims to identify specific factors released from bones that may contribute to the deterioration of blood vessels as people age. By studying the effects of these factors, such as PDGF-BB, on vascular health, the research seeks to uncover mechanisms that could lead to improved treatments for age-related cardiovascular diseases. Patients may be involved in understanding how their bone health impacts their vascular system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those with concerns about bone health or cardiovascular issues.
Not a fit: Patients under the age of 65 or those without any vascular or bone health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cardiovascular diseases in older adults.
How similar studies have performed: Previous studies have indicated a connection between bone health and vascular aging, suggesting that this research builds on established findings rather than exploring entirely novel territory.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Wan, Mei — Johns Hopkins University
- Study coordinator: Wan, Mei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.