Investigating how Factor XIIa activates renin in heart failure.
Official title: Factor XIIa is the long-sought activator of circulating renin in heart failure.
Funded at University of Arizona · NIH-10978451 · Data updated 2026-11-12
This study is looking at how a specific protein called Factor XIIa helps activate an important enzyme related to heart failure, especially in people with dilated cardiomyopathy, to find new ways to slow down heart problems and help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $461,556 |
| NIH project number | 1R01HL171366-01A1 |
| Project ID | NIH-10978451 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure, particularly those with reduced ejection fraction and dilated cardiomyopathy.
✕Less likely to help
Patients without heart failure or those with other unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Factor XIIa in activating renin, a key enzyme involved in heart failure. By examining how this activation occurs in patients with dilated cardiomyopathy, the study aims to uncover mechanisms that contribute to heart dysfunction. The approach includes laboratory techniques such as enzymology and biomarker analysis, alongside modeling heart failure in living organisms. The ultimate goal is to identify new strategies to prevent the progression of heart failure and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of heart failure.
How similar studies have gone: Previous research has shown promising results in understanding the role of renin in heart failure, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Gladysheva, Inna P — University of Arizona
- Study coordinator: Gladysheva, Inna P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.