Investigating how F-BAR proteins influence neuron development and movement
F-BAR proteins in neuronal migration and process formation
This study is looking at how certain proteins help brain cells move and grow, which is important for developing a healthy brain, and it uses special techniques to see how changing these proteins affects the brain cells' behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10880554 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of F-BAR proteins in the development of neurons, particularly how these proteins help neurons migrate and form their processes. By studying the coordination between the actin cytoskeleton and the plasma membrane, the research aims to uncover the mechanisms that allow neurons to extend their axons and dendrites effectively. The approach involves advanced techniques, including CRISPR, to manipulate these proteins and observe their effects on neuronal behavior in a controlled environment. This could provide insights into fundamental processes that are crucial for brain development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with developmental neurological disorders or conditions affecting brain structure and function.
Not a fit: Patients with fully developed neurological systems or those not affected by neuronal migration issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders related to neuronal migration and process formation.
How similar studies have performed: Other research has shown promising results in understanding neuronal development through similar approaches, particularly using CRISPR technology to manipulate gene functions.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Dent, Erik W — University of Wisconsin-Madison
- Study coordinator: Dent, Erik W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.