Investigating how extrachromosomal DNA affects cancer growth and treatment resistance
eDyNAmiC - STANFORD
This study is looking into how a special type of DNA called extrachromosomal DNA helps cancer grow and become tougher to treat, with the goal of finding new ways to target it for better treatments for cancer patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10625716 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of extrachromosomal DNA (ecDNA) in cancer, which allows tumor-promoting genes to escape from chromosomes and form circular DNA structures. These ecDNAs enable tumors to grow aggressively and evolve rapidly, making them more resistant to treatments. The study aims to uncover how ecDNAs function, how they contribute to cancer progression, and how they can be targeted for more effective therapies. By collaborating with a team of experts, the research seeks to fill critical gaps in knowledge about ecDNA and its implications for cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients whose tumors contain extrachromosomal DNA.
Not a fit: Patients with cancers that do not involve extrachromosomal DNA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that specifically target ecDNA, potentially improving survival rates for cancer patients.
How similar studies have performed: While the concept of ecDNA has been recognized for decades, this research is pioneering in its comprehensive approach to understanding and targeting ecDNA in cancer treatment.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mischel, Paul S — Stanford University
- Study coordinator: Mischel, Paul S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.