Investigating how extrachromosomal DNA affects cancer growth and treatment resistance
eDyNAmiC - NYU
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10625171
This study is looking into how a special type of DNA called extrachromosomal DNA (ecDNA) helps cancer grow and resist treatments, with the goal of finding new ways to target it and improve outcomes for patients with different types of cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10625171 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of extrachromosomal DNA (ecDNA) in cancer, which allows tumor-promoting genes to escape from chromosomes and form circular DNA structures. These ecDNAs enable tumors to grow more aggressively and evade treatments, leading to poorer patient outcomes. The study aims to explore how ecDNA forms, functions, and evolves, as well as its impact on the immune system and potential targeting strategies. By bringing together a team of experts, the research seeks to fill critical gaps in knowledge about ecDNA in various cancer types.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients whose tumors contain extrachromosomal DNA.
Not a fit: Patients with cancers that do not involve extrachromosomal DNA may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for aggressive cancers that harbor ecDNA, potentially improving survival rates for affected patients.
How similar studies have performed: While the concept of ecDNA has been recognized for decades, recent advancements in understanding its role in cancer are still emerging, indicating that this research is at the forefront of a novel area of investigation.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOEKE, JEF D — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: BOEKE, JEF D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.