Investigating how exposure to certain flame retardants affects aging in the brain and metabolism.
Official title: The impact of organophosphate flame-retardant exposure on metabolic and brain aging
Funded at Texas A&m Agrilife Research · NIH-10952637 · Data updated 2026-11-12
This study is looking at how long-term exposure to certain chemicals found in everyday products might affect aging in our bodies and brains, especially by examining changes in gut health and metabolism, to help us understand any health risks they may pose.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m Agrilife Research NIH-funded |
| Lab location | 1 site (College Station, UNITED STATES) |
| Project start | September 16, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $409,508 |
| NIH project number | 1R21ES036683-01 |
| Project ID | NIH-10952637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of all ages who have been exposed to organophosphate flame retardants, particularly those experiencing cognitive decline or metabolic issues.
✕Less likely to help
Patients who have not been exposed to organophosphate flame retardants or who do not exhibit any signs of cognitive or metabolic dysfunction may not benefit from this research.
What this research studies
This research examines the effects of organophosphate flame retardants (OPFRs) on metabolic and brain aging. It focuses on how long-term exposure to these chemicals, which are commonly found in the environment, may influence health outcomes related to aging. The study will analyze changes in gut microbiota, inflammation, and metabolic processes in individuals exposed to OPFRs, using advanced techniques like serum metabolomics to identify relevant biomarkers. By understanding these relationships, the research aims to shed light on potential health risks associated with OPFR exposure.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of health risks related to aging and exposure to environmental pollutants.
How similar studies have gone: Previous research has indicated potential links between environmental pollutants and health outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Texas A&m Agrilife Research
College Station, United States Active
Researchers
- Principal investigator: Wu, Chia-Shan — Texas A&m Agrilife Research
- Study coordinator: Wu, Chia-Shan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.