Investigating how exposure to BPA affects liver cancer development
Official title: Understanding mechanisms of liver carcinogenesis following developmental BPA exposure
Funded at Oregon Health & Science University · NIH-11098186 · Data updated 2026-11-12
This study is looking at how being around a chemical called BPA might lead to health problems like metabolic syndrome, which can cause issues like diabetes and liver cancer, and it aims to find ways to help prevent and treat these conditions for people who are at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | December 20, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $140,877 |
| NIH project number | 3R01ES034836-03S1 |
| Project ID | NIH-11098186 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals exposed to BPA and those at risk for metabolic syndrome, particularly adults under 21 years old.
✕Less likely to help
Patients who are not exposed to BPA or do not have risk factors for metabolic syndrome may not benefit from this research.
What this research studies
This research explores the link between exposure to bisphenol A (BPA) and the development of metabolic syndrome (MetS), which can lead to serious health issues like type II diabetes and liver cancer. The study aims to understand the biological mechanisms by which BPA contributes to lipid accumulation in the liver and insulin resistance, focusing on specific proteins and signaling pathways involved. By identifying these mechanisms, the research seeks to provide insights into preventing and treating conditions associated with MetS. Patients may benefit from improved prevention strategies and treatments based on the findings.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for metabolic syndrome and related diseases.
How similar studies have gone: Previous research has shown a correlation between BPA exposure and metabolic syndrome, but this study aims to provide novel mechanistic insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Weinhouse, Caren — Oregon Health & Science University
- Study coordinator: Weinhouse, Caren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.