Investigating how exposure to bisphenol A affects liver cancer development
Understanding mechanisms of liver carcinogenesis following developmental BPA exposure
This study is looking at how being exposed to a chemical called BPA while developing might increase the risk of liver cancer later on, and it's aimed at helping us understand more about this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10973603 on NIH RePORTER |
What this research studies
This research explores the link between exposure to bisphenol A (BPA) during development and the subsequent risk of liver cancer, specifically hepatocellular carcinoma (HCC). By using animal models, the study examines how BPA exposure can lead to cancer initiation and promotion in the liver. The researchers aim to understand the biological mechanisms involved, including the role of reactive oxygen species in cancer development. This could provide insights into new risk factors for liver cancer that are not yet fully understood.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of exposure to environmental pollutants, particularly bisphenol A, and those at risk for liver cancer.
Not a fit: Patients who have no history of exposure to environmental carcinogens or who are not at risk for liver cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and interventions for liver cancer, particularly for those at risk due to environmental exposures.
How similar studies have performed: Previous research has indicated that environmental pollutants like BPA can contribute to cancer development, suggesting that this approach has potential backing from earlier findings.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Weinhouse, Caren — Oregon Health & Science University
- Study coordinator: Weinhouse, Caren
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.