Investigating how exposure to bisphenol A affects liver cancer development
Official title: Understanding mechanisms of liver carcinogenesis following developmental BPA exposure
Funded at Oregon Health & Science University · NIH-10973603 · Data updated 2026-11-12
This study is looking at how being exposed to a chemical called BPA while developing might increase the risk of liver cancer later on, and it's aimed at helping us understand more about this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | December 20, 2022 |
| Project end | October 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $491,377 |
| NIH project number | 5R01ES034836-03 |
| Project ID | NIH-10973603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of exposure to environmental pollutants, particularly bisphenol A, and those at risk for liver cancer.
✕Less likely to help
Patients who have no history of exposure to environmental carcinogens or who are not at risk for liver cancer may not benefit from this research.
What this research studies
This research explores the link between exposure to bisphenol A (BPA) during development and the subsequent risk of liver cancer, specifically hepatocellular carcinoma (HCC). By using animal models, the study examines how BPA exposure can lead to cancer initiation and promotion in the liver. The researchers aim to understand the biological mechanisms involved, including the role of reactive oxygen species in cancer development. This could provide insights into new risk factors for liver cancer that are not yet fully understood.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and interventions for liver cancer, particularly for those at risk due to environmental exposures.
How similar studies have gone: Previous research has indicated that environmental pollutants like BPA can contribute to cancer development, suggesting that this approach has potential backing from earlier findings.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Weinhouse, Caren — Oregon Health & Science University
- Study coordinator: Weinhouse, Caren
Related research
Other NIH-funded projects on the same topics.
-
Understanding how a protein affects nerve cell movement in Alzheimer's disease
This study is looking at how a protein called APP affects the growth and movement of nerve cells, which is important for understanding Alzheimer's disease, and it aims to find out how problems with this protein might lead to nerve cell damage.
-
Understanding how the bone marrow environment drives AML resistance
A large NIH-funded project at Oregon Health & Science University is studying how the body’s own cell surroundings help acute myeloid leukemia become resistant to treatment, with potential paths to better therapies for patients.
-
Improving Safety at Work with a Low-Resource mHealth Program in Malaysia (and beyond)
A low-cost mobile health program to improve safety culture in Malaysian workplaces, with plans to adapt the approach for U.S. workers in high-risk industries.
-
Oregon Healthy Workplace Initiative for Better Health
A multi-site effort aims to improve the health and safety of workers by coordinating research, tools, and interventions across workplaces.
-
Understanding how AML cells become resistant to therapy over time
This project looks at why acute myeloid leukemia stops responding to treatment and how to design better drug combinations to prevent relapse.
-
Mechanisms and Countermeasures for Ultra-Potent Synthetic Opioid Overdose
A small, focused NIH grant aims to understand why ultra-potent synthetic opioids cause severe overdose and to explore potential countermeasures to keep people safe.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.