Investigating how exosomes relate to Alzheimer's disease and concussion effects
Exosome biology in Alzheimer's disease and concussion
This study is looking at how tiny particles called exosomes, released by brain cells, might help us understand the connection between repeated concussions and the risk of developing Alzheimer's disease, specifically in NCAA Division I athletes who have had multiple mild brain injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11075857 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of exosomes, which are tiny particles released by cells, in the context of Alzheimer's disease and the effects of repeated concussions. By studying a group of NCAA Division I athletes who have experienced multiple mild traumatic brain injuries (mTBIs), the researchers aim to identify reliable blood biomarkers that could predict the risk of developing Alzheimer's disease or related dementias. The study will differentiate between exosomes derived from neurons and astrocytes to assess their relationship with cognitive dysfunction and brain health. Through this approach, the research seeks to uncover biological mechanisms that link mTBIs to long-term neurological outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include NCAA Division I athletes who have experienced multiple concussions.
Not a fit: Patients who have not experienced concussions or are not involved in high-impact sports may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of blood tests that help predict the risk of Alzheimer's disease in individuals who have suffered concussions.
How similar studies have performed: While there is ongoing research into the effects of concussions on brain health, this specific approach using exosomes is relatively novel and has not been extensively tested.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Granholm-Bentley, Ann-Charlotte Esther — University of Colorado Denver
- Study coordinator: Granholm-Bentley, Ann-Charlotte Esther
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.