Investigating how exosomes influence the spread of metastatic breast cancer
A physical sciences approach to investigate the role of exosomes in metastatic progression
This study is looking at how tiny particles released by cancer cells might help triple-negative breast cancer spread and avoid the immune system, with the hope of finding new ways to treat this type of cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10903978 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of exosomes, which are tiny particles released by cancer cells, in the progression of metastatic triple-negative breast cancer (TNBC). The team will explore how the stiffness of the surrounding tissue and the mechanical tension within cells affect the production and content of these exosomes. By studying these interactions, the research aims to uncover how exosomes contribute to the suppression of the immune response against tumors and facilitate cancer spread. Patients may benefit from insights that could lead to new therapeutic strategies targeting exosome behavior in TNBC.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with triple-negative breast cancer who are experiencing or at risk of metastatic progression.
Not a fit: Patients with non-metastatic breast cancer or other types of cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the immune response against metastatic breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of exosomes in cancer progression, indicating that this approach has potential for significant findings.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Radhakrishnan, Ravi — University of Pennsylvania
- Study coordinator: Radhakrishnan, Ravi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.