Investigating how exosomes from heart cells can improve heart function in patients with heart failure.
Exosome Therapeutics to Dissect HFpEF Mechanisms
This study is looking at a heart condition called HFpEF and is testing how tiny particles from heart cells, called exosomes, might help improve heart function and reduce inflammation, with the hope of finding new treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10877714 on NIH RePORTER |
What this research studies
This research focuses on heart failure with preserved ejection fraction (HFpEF), a condition with limited treatment options. The team is exploring the use of exosomes, which are small particles released by heart cells, to understand their role in improving heart function and reducing inflammation. By analyzing the molecular signatures associated with HFpEF and the effects of exosomes from cardiosphere-derived cells, the researchers aim to identify new therapeutic targets that could lead to effective treatments for patients. This approach combines advanced molecular techniques with cell therapy insights to potentially revolutionize care for those suffering from HFpEF.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with heart failure with preserved ejection fraction (HFpEF).
Not a fit: Patients with heart failure due to reduced ejection fraction or other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for patients with heart failure, improving their quality of life and reducing symptoms.
How similar studies have performed: Previous research has shown promise in using cell-derived exosomes for cardiac therapies, indicating a potential for success in this novel approach.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Van Eyk, Jennifer E — Cedars-Sinai Medical Center
- Study coordinator: Van Eyk, Jennifer E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.