Investigating how exosomes contribute to the progression of head and neck cancer

Who could benefit from this research

What this research studies

This research focuses on exosomes, which are tiny vesicles released by cancer cells that may play a significant role in the progression of head and neck squamous cell carcinoma (HNSCC). The study aims to understand how these exosomes, particularly those influenced by a protein called cortactin, contribute to cancer spread and the formation of new blood vessels. By examining the molecular contents of exosomes and their interactions with cancer cells, the researchers hope to uncover new insights into cancer behavior and potential therapeutic targets. Patients may benefit from findings that could lead to improved treatments or diagnostic tools based on exosomal biomarkers.

Why it matters

Where this research is happening

• Vanderbilt University
  Nashville, United States Active

Researchers

• Principal investigator: Weaver, Alissa M — Vanderbilt University
• Study coordinator: Weaver, Alissa M

Related research

Other NIH-funded projects on the same topics.

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• Data-driven classification of aggressive tissue traits to predict cancer outcomes in HPV-negative head and neck cancer

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  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11505841

• HNSCC, iron addiction, and potential iron-targeted therapies

  This grant explores how head and neck cancer cells become dependent on iron and whether targeting iron pathways could lead to new treatments for patients with recurrent or metastatic disease.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11441057

• Targeting SREBP2 to boost radiation therapy in HPV-negative head and neck cancer

  This grant aims to see if blocking SREBP2 can make radiation therapy work better for people with HPV-negative Head and Neck Squamous Cell Carcinoma.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11427724

• Axelopran added to pembrolizumab for frontline recurrent/metastatic head and neck cancer

  A new treatment approach combines axelopran with pembrolizumab for people with PD-L1 positive recurrent/metastatic head and neck cancer to see if it improves response.

  NIH research Glycyx Mor, INC. · San Francisco, United States · NIH-11418514

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.