Investigating how exosome treatment affects brain waste clearance in diabetes
Official title: Imaging cerebral waste clearance responses during exosome treatment of diabetes
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11073117 · Data updated 2026-11-12
This study is looking at how diabetes affects the brain's ability to get rid of waste, which is important for keeping our thinking sharp, and it’s exploring how tiny particles from brain cells might help improve this process for people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $551,682 |
| NIH project number | 5R01DK136843-02 |
| Project ID | NIH-11073117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with diabetes and are experiencing cognitive decline.
✕Less likely to help
Patients without diabetes or those who do not exhibit cognitive decline may not benefit from this research.
What this research studies
This research explores the impact of diabetes on the brain's ability to clear waste, which is crucial for cognitive health. It focuses on using exosomes, tiny particles released by brain cells, to improve waste clearance and cognitive function in diabetic conditions. The study employs advanced imaging techniques to observe changes in brain function and waste removal pathways. By understanding these mechanisms, the research aims to identify potential therapeutic strategies for cognitive decline associated with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance cognitive function and brain health in individuals with diabetes.
How similar studies have gone: Previous research has shown promising results using exosome treatments in animal models, indicating potential for success in human applications.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Jiang, Quan — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Jiang, Quan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.