Investigating how exogenous AMH affects ovarian function and fertility
Official title: Evaluation of the effect of exogenous AMH on ovarian function and fertility
Funded at Massachusetts General Hospital · NIH-11141413 · Data updated 2026-11-12
This study is looking at how a hormone called anti-Müllerian hormone (AMH) affects women's ovaries, with the goal of finding out if it can help improve fertility or be used for contraception, which could lead to new treatments for fertility problems and age-related ovarian issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 5, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $724,714 |
| NIH project number | 1R01HD115719-01A1 |
| Project ID | NIH-11141413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing fertility issues or those at risk of ovarian aging due to medical treatments.
✕Less likely to help
Patients who are not seeking to conceive or who have no concerns regarding ovarian function may not benefit from this research.
What this research studies
This research explores the role of anti-Müllerian hormone (AMH) in regulating ovarian function and its potential applications in women's health. By using non-human primates as a model, the study aims to understand how AMH can inhibit follicle activation and growth, and whether higher levels of AMH can safely enhance fertility or provide contraception. The findings could lead to new treatments for conditions related to ovarian aging and fertility issues. The research will involve administering AMH and monitoring its effects on ovarian function over time.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve fertility and protect against ovarian aging in women.
How similar studies have gone: While research on AMH has been conducted in animal models, this approach using non-human primates is relatively novel and aims to bridge the gap in understanding its effects in humans.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Pepin, David — Massachusetts General Hospital
- Study coordinator: Pepin, David
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.