Investigating how exercise and a specific protein can help improve blood vessel function in pulmonary hypertension.
Official title: Role for Nrf2 and exercise in mitigating pulmonary hypertension-induced vascular dysfunction
Funded at Kansas State University · NIH-10929362 · Data updated 2026-11-12
This study is looking at how pulmonary hypertension affects blood vessels and whether exercise and a special protein called Nrf2 can help improve blood flow and oxygen delivery for people with this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $36,922 |
| NIH project number | 5F31HL170643-02 |
| Project ID | NIH-10929362 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pulmonary hypertension who may benefit from improved vascular function.
✕Less likely to help
Patients without pulmonary hypertension or those with advanced heart failure may not receive benefit from this research.
What this research studies
This research focuses on understanding how pulmonary hypertension (PH) affects blood vessel function and how exercise, along with the activation of a protein called Nrf2, may help improve this dysfunction. By examining the physiological and molecular changes in the body, the study aims to identify potential therapeutic targets that could enhance blood flow and oxygen delivery in patients with PH. The research will utilize animal models to explore these mechanisms and assess the impact of exercise on vascular health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel function and overall health for patients with pulmonary hypertension.
How similar studies have gone: While the specific approach of combining exercise and Nrf2 activation in PH is novel, similar studies have shown promise in improving vascular function through other therapeutic strategies.
Where this research is happening
-
Kansas State University
Manhattan, United States Active
Researchers
- Principal investigator: Schulze, Kiana Marie — Kansas State University
- Study coordinator: Schulze, Kiana Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.