Investigating how exercise affects heart function and frailty in patients receiving stem cell transplants.
Official title: The Relationship of Exercise Associated Cardiac Reserve on Peak Oxygen Consumption and Frailty Measures in Individuals Undergoing Allogeneic Hematopoietic Stem Cell Transplant.
Funded at Virginia Commonwealth University · NIH-11017762 · Data updated 2026-11-12
This study is looking at how exercise ability relates to heart health in patients getting a special type of stem cell transplant, using safe MRI scans to measure how well they can use oxygen during exercise, with the goal of finding ways to help them feel better and recover faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $149,048 |
| NIH project number | 5K23HL159270-03 |
| Project ID | NIH-11017762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing allogeneic hematopoietic stem cell transplantation for hematologic malignancies.
✕Less likely to help
Patients who are not undergoing stem cell transplantation or those with non-hematologic conditions may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between exercise capacity and heart function in patients undergoing allogeneic hematopoietic stem cell transplantation. Using advanced cardiovascular magnetic resonance imaging (MRI), the study aims to measure peak oxygen consumption, which is crucial for assessing overall health and recovery. The noninvasive approach eliminates risks associated with traditional imaging methods, making it safer for patients with compromised health. By collaborating with experts from various fields, the research seeks to identify factors that can improve exercise capacity and quality of life for these patients.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise capacity and quality of life for patients undergoing stem cell transplants.
How similar studies have gone: Similar research has shown promise in using advanced imaging techniques to assess cardiac function in cancer patients, indicating potential for success in this novel approach.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Canada, Justin Mcnair — Virginia Commonwealth University
- Study coordinator: Canada, Justin Mcnair
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-
Targeting early oral GVHD to improve mouth health after stem cell transplant
A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.