Investigating how exercise affects brain changes in patients with cervical dystonia.
Progressive resistance exercise and dystonia pathophysiology.
This study is looking at how a special exercise program can help people with cervical dystonia feel better, and it will compare the results of those doing the exercises along with their usual treatments to those just getting the standard care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10911116 on NIH RePORTER |
What this research studies
This research focuses on understanding how progressive resistance exercise can improve symptoms in patients with cervical dystonia, a movement disorder characterized by involuntary muscle contractions. The study will involve patients participating in a program that combines this exercise with standard medical treatments. Using advanced imaging techniques like functional MRI and transcranial magnetic stimulation, researchers aim to uncover the brain changes associated with this exercise approach. By comparing outcomes between those receiving the exercise intervention and those receiving standard care alone, the study seeks to provide insights into the variability of treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with focal cervical dystonia who are currently receiving standard medical treatment.
Not a fit: Patients with other forms of dystonia or those who do not respond to standard treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with cervical dystonia, improving their quality of life.
How similar studies have performed: Previous studies have shown some success with exercise therapy in managing dystonia symptoms, but this approach focusing on progressive resistance exercise is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Wagle Shukla, Aparna — University of Florida
- Study coordinator: Wagle Shukla, Aparna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.