Investigating how estrogen-related receptors affect kidney health in older adults
Role of Estrogen Related Receptors in Age Related Kidney Disease
This study is looking at how certain receptors in the body can help keep our kidneys healthy as we get older, and it’s testing whether a special treatment can help fix kidney problems in older mice, with the hope of finding new ways to support kidney health for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10981642 on NIH RePORTER |
What this research studies
This research explores the role of estrogen-related receptors (ERRs) in kidney health as people age. It examines how lifelong caloric restriction can prevent the decline in kidney function associated with aging and how ERRs can be targeted to improve kidney health. The study involves testing the effects of ERR agonists in aged mice to understand their potential benefits in reversing kidney damage and inflammation. By identifying the mechanisms through which ERRs influence kidney disease, the research aims to develop new therapeutic strategies for older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who may be experiencing age-related kidney issues.
Not a fit: Patients with acute kidney failure or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve kidney health and function in older adults.
How similar studies have performed: Previous research has shown promising results in targeting estrogen-related receptors for improving health outcomes, suggesting potential for success in this area.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Levi, Moshe — Georgetown University
- Study coordinator: Levi, Moshe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.