Investigating how estrogen receptor beta affects inflammatory breast cancer progression and spread
Exploring the role of estrogen receptor beta in progression and metastasis ofInflammatory breast cancer
['FUNDING_R01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-10753521
This study is looking at how a specific protein called estrogen receptor beta might affect the growth and spread of inflammatory breast cancer, with the hope of finding new treatments that could help improve survival for patients facing this tough diagnosis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10753521 on ClinicalTrials.gov |
What this research studies
This research focuses on inflammatory breast cancer (IBC), a particularly aggressive form of breast cancer with a poor prognosis. The study aims to understand the role of estrogen receptor beta (ERβ) in the progression and metastasis of IBC by analyzing tumor tissues and utilizing preclinical models. Researchers will explore how ERβ influences cell migration and metastasis, potentially identifying new therapeutic targets for patients with IBC. The findings could lead to the development of targeted therapies that improve survival outcomes for patients suffering from this lethal disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with inflammatory breast cancer, particularly those with tumors expressing estrogen receptor beta.
Not a fit: Patients with other forms of breast cancer or those whose tumors do not express estrogen receptor beta may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that significantly improve survival rates for patients with inflammatory breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting estrogen receptors in other types of breast cancer, suggesting potential for success in this novel approach for inflammatory breast cancer.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, CHRISTOFOROS — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: THOMAS, CHRISTOFOROS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancers, neoplasm/cancer