Investigating how estrogen pathways contribute to prostate issues and urinary problems
Estrogen pathways in the development of prostatic fibrosis and lower urinary tract dysfunction
This study is looking into how estrogen affects prostate growth and urinary issues in older men, with the goal of finding better treatments for these common problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10813129 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of estrogen pathways in the development of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) in men. It aims to identify the anatomical, cellular, and molecular causes of these conditions, which affect many older men and can lead to severe complications. By exploring these pathways, the research seeks to develop more effective therapies beyond the current treatments that primarily target smooth muscle contractility. The study involves analyzing prostatic collagen deposition and its relationship with prostate stiffness and urinary symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are older men experiencing symptoms of benign prostatic hyperplasia or lower urinary tract dysfunction.
Not a fit: Patients who are not experiencing urinary tract symptoms or do not have benign prostatic hyperplasia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective treatments for men suffering from BPH and LUTS.
How similar studies have performed: Previous research has shown promising results in understanding the role of estrogen in prostate health, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Ricke, William a — University of Wisconsin-Madison
- Study coordinator: Ricke, William a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.