Investigating how estrogen and glucocorticoid receptors interact in breast cancer
Estrogen and glucocorticoid receptor crosstalk in ER+ breast
This study is looking at how two important proteins, estrogen and glucocorticoid receptors, work together in early-stage breast cancer to see how they affect tumor growth and patient recovery, with the hope of finding better treatment options for those with estrogen receptor-positive breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10799553 on NIH RePORTER |
What this research studies
This research explores the relationship between estrogen and glucocorticoid receptors in early-stage breast cancer, particularly how their interaction affects tumor behavior and patient outcomes. The study will analyze tumor samples from patients to understand how glucocorticoid receptor activity influences estrogen receptor function and gene expression related to cancer progression. By using cell line models, researchers aim to uncover the molecular mechanisms that govern these interactions, which could lead to improved treatment strategies for patients with ER+ breast cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage estrogen receptor-positive breast cancer.
Not a fit: Patients with breast cancer that does not express estrogen receptors or those with advanced-stage breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with estrogen receptor-positive breast cancer, potentially improving survival rates.
How similar studies have performed: Previous research has shown promising results in understanding receptor interactions in breast cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Conzen, Suzanne Daniela — Ut Southwestern Medical Center
- Study coordinator: Conzen, Suzanne Daniela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.