Investigating how estrogen affects immune responses and autoimmune diseases.
Examining Sexual Dimorphisms: The Role of Estradiol Signaling in Modulating Immunity
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-10974352
This study is looking at how the hormone estradiol affects the immune system differently in men and women, specifically in women with a rare lung disease called LAM, to help us understand how hormonal changes might influence this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10974352 on ClinicalTrials.gov |
What this research studies
This research explores the differences in immune responses between genders, particularly focusing on how the hormone estradiol influences these responses. The study examines a rare lung disease called lymphangioleiomyomatosis (LAM), which predominantly affects women and is sensitive to estrogen levels. By using animal models, the researchers aim to understand the mechanisms by which estradiol impacts immune function and contributes to the progression of LAM. This could lead to new insights into how hormonal changes affect autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with lymphangioleiomyomatosis or other estrogen-sensitive autoimmune conditions.
Not a fit: Patients who do not have estrogen-sensitive autoimmune diseases or who are male may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases that are influenced by hormonal changes.
How similar studies have performed: Previous research has shown promising results in understanding the role of hormones in immune function, suggesting that this approach could yield valuable insights.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAMMES, STEPHEN R. — UNIVERSITY OF ROCHESTER
- Study coordinator: HAMMES, STEPHEN R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.