Investigating how estrogen affects heart function differences between sexes in pulmonary arterial hypertension.
Multi-scale Investigation of Sex Differences in Right Ventricular Function via Estrogen-Microtubule Interactions
This study is looking at how estrogen affects the right side of the heart in people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to help improve heart function for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11066466 on NIH RePORTER |
What this research studies
This research focuses on understanding how estrogen influences right ventricular function in patients with pulmonary arterial hypertension (PAH), a serious condition that affects blood vessels in the lungs. The study will explore the role of estrogen in regulating microtubules, which are essential components of cell structure and function. Using advanced microscopy and computational techniques, researchers will analyze how these interactions affect heart function. The findings could lead to new therapeutic strategies that specifically target right ventricular dysfunction in PAH patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those experiencing right ventricular dysfunction.
Not a fit: Patients without pulmonary arterial hypertension or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for right ventricular dysfunction in patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in cardiovascular diseases, but this specific approach focusing on estrogen and microtubule interactions is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Prins, Kurt W — University of Minnesota
- Study coordinator: Prins, Kurt W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.