Investigating how estrogen affects gene regulation in cells
Novel Coregulators of Estrogen Receptor in Enhancer-regulated Transcription
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-10549772
This study is looking at how estrogen and its receptors work together to control gene activity, especially in organs like the breasts, to help us understand issues like hormone resistance and developmental problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10549772 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of estrogen and its receptor in regulating gene expression, particularly in relation to diseases affecting organs like the mammary glands. The team is exploring how specific proteins interact with estrogen receptors at gene enhancers, which are regions of DNA that help control when and how genes are turned on or off. By using advanced techniques to study these interactions, the researchers aim to uncover the mechanisms that lead to normal and abnormal cellular responses to estrogen. This could provide insights into conditions such as hormone resistance and developmental defects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hormone-related conditions, particularly those affecting the mammary glands.
Not a fit: Patients who do not have hormone-related conditions or those not affected by estrogen signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating hormone-related diseases and improving patient outcomes.
How similar studies have performed: Other research has shown promising results in understanding estrogen receptor interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIU, ZHIJIE "JASON" — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: LIU, ZHIJIE "JASON"
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.