Investigating how estrogen affects eye pressure regulation
Official title: Estrogen and its Receptor in Intraocular Pressure Regulation
Funded at Augusta University · NIH-11042823 · Data updated 2026-11-12
This study is looking at how estrogen affects eye pressure and could help find new treatments for people with primary open-angle glaucoma by exploring how it influences the cells that drain fluid from the eye.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $383,430 |
| NIH project number | 5R01EY032960-03 |
| Project ID | NIH-11042823 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are affected by primary open-angle glaucoma.
✕Less likely to help
Patients with other forms of glaucoma or those who are not affected by elevated intraocular pressure may not benefit from this research.
What this research studies
This research focuses on understanding the role of estrogen and its receptors in regulating intraocular pressure (IOP), which is crucial for patients with primary open-angle glaucoma (POAG). The study examines how estrogen influences the trabecular meshwork and Schlemm's canal cells, which are responsible for draining fluid from the eye. By identifying novel therapeutic targets related to estrogen pathways, the research aims to improve treatment options for lowering IOP in glaucoma patients. The approach includes bioinformatics analyses of genetic data to explore associations between estrogen-related genes and IOP.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that more effectively lower eye pressure in glaucoma patients, potentially preserving their vision.
How similar studies have gone: Previous research has shown promising results in exploring estrogen's role in eye health, but this specific approach is relatively novel.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Liu, Yutao — Augusta University
- Study coordinator: Liu, Yutao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.