Investigating how estrogen affects brain cells to help prevent obesity and metabolic issues
ESTROGEN-INDUCIBLE PNNS ENHANCE EXCITATORY SYNAPTIC STRENGTH ONTO GABA NEURONS IN THE MEPD TO PREVENT OBESITY AND METABOLIC DYSREGULATION
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11114055
This study is looking at how special structures in the brain help certain nerve cells work together to control hunger and energy balance, especially in women, to find new ways to help manage weight and improve health for those dealing with obesity.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11114055 on ClinicalTrials.gov |
What this research studies
This research explores the role of perineuronal nets (PNNs) in the brain, which are structures that support and protect certain neurons. The focus is on how these nets interact with GABA neurons in the medial amygdala to influence energy balance and prevent overeating. By studying the effects of estrogen on these neurons, the research aims to uncover mechanisms that could help regulate body weight and metabolic health. Patients may benefit from insights that could lead to new treatments for obesity and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or metabolic dysregulation, particularly those who may have hormonal influences on their condition.
Not a fit: Patients who are not affected by obesity or metabolic disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing obesity and improving metabolic health.
How similar studies have performed: Previous research has shown promising results in understanding the role of PNNs in metabolic regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, CHUNMEI — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: WANG, CHUNMEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder