Investigating how estradiol affects brain responses to rewards in women experiencing menopause-related mood disorders.
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
This study is looking at how hormonal changes during menopause affect mood issues like feeling less pleasure and experiencing psychosis, and it's for women going through perimenopause to help find better ways to treat these feelings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11001915 on NIH RePORTER |
What this research studies
This research focuses on understanding how hormonal changes during menopause influence mood disorders, specifically anhedonia and psychosis. By using advanced imaging techniques like PET and fMRI, the study aims to explore the relationship between brain activity related to rewards and the severity of depressive symptoms in women. Participants will be women experiencing perimenopausal symptoms, allowing researchers to identify biological markers that could predict treatment responses and improve outcomes for those affected by these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing perimenopausal symptoms, particularly those with anhedonia and psychosis.
Not a fit: Patients who are not experiencing perimenopausal symptoms or those with other unrelated mood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted treatments for women suffering from mood disorders during menopause.
How similar studies have performed: Previous research has shown promise in using imaging techniques to study brain responses in mood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Dichter, Gabriel S — Univ of North Carolina Chapel Hill
- Study coordinator: Dichter, Gabriel S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.