Investigating how ESCO1 affects DNA organization in cells
Official title: Defining a direct mechanism of ESCO1 in chromatin organization
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10998786 · Data updated 2026-11-12
This study is looking at how a special enzyme called ESCO1 helps organize DNA in our cells, which could lead to new ways to understand and treat genetic disorders related to chromosome issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $39,419 |
| NIH project number | 1F31GM151889-01A1 |
| Project ID | NIH-10998786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or conditions related to chromosomal organization and stability.
✕Less likely to help
Patients with conditions unrelated to chromosomal organization or those not affected by genetic disorders may not receive benefit from this research.
What this research studies
This research explores the role of ESCO1, an enzyme that modifies a protein called Cohesin, which is crucial for organizing DNA within the cell nucleus. By understanding how ESCO1 influences the structure and function of chromatin, the research aims to uncover new mechanisms that regulate gene expression and chromosome stability. The study will involve experiments to observe how ESCO1 interacts with DNA and other proteins, potentially revealing novel insights into cellular processes. Patients may benefit from this research as it could lead to advancements in understanding genetic disorders linked to chromosomal abnormalities.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic regulation and lead to new treatments for diseases caused by chromosomal dysfunction.
How similar studies have gone: While the specific mechanisms of ESCO1 are being explored, similar research has shown promise in understanding chromatin dynamics and its implications for genetic diseases.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Schoen, Jeffrey R. — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Schoen, Jeffrey R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.