Investigating how Erbb3 kinase activity affects colorectal cancer development.
Role of Erbb3 kinase activity in colorectal tumorigenesis.
This study is looking at how a gene called Erbb3 affects the growth of colorectal cancer and whether certain changes in this gene can help doctors figure out if patients will respond better to a specific type of cancer treatment called anti-PD1 therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11212156 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Erbb3 kinase in the development of colorectal cancer and how mutations in this gene may influence the effectiveness of anti-PD1 antibody therapy. The researchers will explore the mechanisms by which Erbb3 contributes to tumor growth and assess whether colorectal cancers with specific Erbb3 mutations respond better to immune checkpoint inhibitors. By using advanced models, including genetically engineered mice, the study aims to uncover critical insights that could lead to improved treatment strategies for patients with colorectal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colorectal cancer, especially those with mutations in the Erbb3 gene.
Not a fit: Patients with colorectal cancer who do not have Erbb3 mutations or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colorectal cancer patients, particularly those with specific Erbb3 mutations.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Wang, Zhenghe — Case Western Reserve University
- Study coordinator: Wang, Zhenghe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.