Investigating how ERBB2 signaling affects HPV-related diseases
Official title: The role of ERBB2 signaling in HPV-induced pathologies
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10895853 · Data updated 2026-11-12
This study is looking at how a specific signaling process in our cells affects the development of diseases caused by high-risk HPV, with the hope of finding new treatments that could help people who are infected with the virus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $76,514 |
| NIH project number | 1F32CA290798-01 |
| Project ID | NIH-10895853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals infected with high-risk HPV strains who are at risk for developing related malignancies.
✕Less likely to help
Patients who are not infected with HPV or those with non-viral related cancers may not benefit from this research.
What this research studies
This research focuses on understanding the role of ERBB2 signaling in the development of diseases caused by high-risk human papillomaviruses (HPV). By utilizing advanced techniques like single-cell RNA sequencing, the study aims to identify specific cell populations in the skin and mucosa that are influenced by HPV infection. The goal is to uncover the mechanisms that lead to cancer development in HPV-infected individuals, which could pave the way for new antiviral therapies. Patients may benefit from insights gained about HPV-induced cellular changes and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral therapies for HPV-related cancers.
How similar studies have gone: Previous research has shown promise in understanding HPV-related pathologies, but this specific approach utilizing single-cell analysis is relatively novel.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Rivera-Cruz, Cosette M — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Rivera-Cruz, Cosette M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.