Investigating how Epstein-Barr virus proteins affect gene regulation
Official title: Epstein-Barr Virus nuclear antigen leader protein in transcription regulation
Funded at University of Minnesota · NIH-11106009 · Data updated 2026-11-12
This study is looking at how a protein from the Epstein-Barr virus affects gene activity in cells, especially in people with HIV, to better understand how it might lead to certain diseases and cancers.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $247,473 |
| NIH project number | 5R00DE030215-05 |
| Project ID | NIH-11106009 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals infected with the Epstein-Barr virus, particularly those with HIV or related B cell malignancies.
✕Less likely to help
Patients who do not have EBV infection or related conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the Epstein-Barr virus (EBV) nuclear antigen leader protein in regulating gene expression. By using EBV-transformed lymphoblastoid cell lines, researchers will explore how this protein interacts with host DNA to influence the development of diseases associated with EBV, particularly in individuals with HIV. The study employs advanced techniques such as CRISPR to identify the mechanisms by which this viral protein contributes to the transformation of B lymphocytes and the progression of related cancers.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating EBV-related diseases and cancers.
How similar studies have gone: Previous research has shown promising results in understanding viral mechanisms in cancer, suggesting potential for success in this area.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Wang, Chong — University of Minnesota
- Study coordinator: Wang, Chong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.