Investigating how Epstein-Barr virus proteins affect gene regulation
Epstein-Barr Virus nuclear antigen leader protein in transcription regulation
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11106009
This study is looking at how a protein from the Epstein-Barr virus affects gene activity in cells, especially in people with HIV, to better understand how it might lead to certain diseases and cancers.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11106009 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the Epstein-Barr virus (EBV) nuclear antigen leader protein in regulating gene expression. By using EBV-transformed lymphoblastoid cell lines, researchers will explore how this protein interacts with host DNA to influence the development of diseases associated with EBV, particularly in individuals with HIV. The study employs advanced techniques such as CRISPR to identify the mechanisms by which this viral protein contributes to the transformation of B lymphocytes and the progression of related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals infected with the Epstein-Barr virus, particularly those with HIV or related B cell malignancies.
Not a fit: Patients who do not have EBV infection or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating EBV-related diseases and cancers.
How similar studies have performed: Previous research has shown promising results in understanding viral mechanisms in cancer, suggesting potential for success in this area.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, CHONG — UNIVERSITY OF MINNESOTA
- Study coordinator: WANG, CHONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus