Investigating how Epstein-Barr virus contributes to cancer in HIV-positive individuals
Epstein-Barr virus LMP1 mediated oncogenicity
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11187589
This study is looking at how the Epstein-Barr virus might contribute to certain types of lymphomas in people with HIV, focusing on a specific virus protein and how it affects immune cells, to better understand why these cancers are more common in those living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11187589 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the Epstein-Barr virus (EBV) in causing various types of lymphomas, particularly in individuals living with HIV. It examines how the EBV oncogene, Latent Membrane Protein 1 (LMP1), influences the development of these cancers and how HIV co-infection affects this process. The study involves analyzing the interactions between EBV and B-cells, which are crucial for the development of these lymphomas, and aims to uncover the mechanisms that lead to increased cancer risk in HIV-positive patients. By utilizing advanced techniques, researchers will explore the specific functions of LMP1 in B-cell transformation and the immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who are living with HIV and at risk for EBV-associated lymphomas.
Not a fit: Patients who are not living with HIV or who do not have a risk of developing EBV-associated lymphomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for lymphomas associated with HIV, potentially reducing cancer risk in these patients.
How similar studies have performed: Previous research has shown a strong association between EBV and various lymphomas in HIV-positive populations, indicating that this area of investigation is both relevant and necessary.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GEWURZ, BENJAMIN ELISON — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: GEWURZ, BENJAMIN ELISON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus