Investigating how Epstein-Barr virus causes B-cell tumors
Roles of LMP1 and MYC in EBV-induced B-cell tumors
This study is looking at how the Epstein-Barr virus might lead to certain types of blood cancers, like Burkitt lymphoma and Hodgkin lymphoma, and aims to create new lab models to better understand how the virus affects B cells, which could help find new ways to treat these cancers.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10917337 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Epstein-Barr virus (EBV) in causing various types of B-cell tumors, including Burkitt lymphoma and Hodgkin lymphoma. The researchers are developing new laboratory models to study how different forms of EBV latency affect the transformation of B cells into cancerous cells. By using a modified version of the virus, they aim to create a stable infection system that mimics the conditions under which these tumors develop in humans. This could lead to better insights into the mechanisms of EBV-induced cancers and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with EBV-associated B-cell lymphomas or those at high risk for developing these conditions.
Not a fit: Patients with B-cell tumors not associated with Epstein-Barr virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with EBV-related B-cell tumors.
How similar studies have performed: While research on EBV and its role in lymphomas has been conducted, this approach using a novel culture system is relatively new and untested.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Kenney, Shannon Celeste — University of Wisconsin-Madison
- Study coordinator: Kenney, Shannon Celeste
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.